The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

  • Richard J. Kowalski, Paraskevi Giannakakou, Sarath P. Gunasekera, Ross E. Longley, Billy W. Day, Ernest Hamel
  • Molecular Pharmacology, October 1997, American Society for Pharmacology & Experimental Therapeutics (ASPET)
  • DOI: 10.1124/mol.52.4.613

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http://dx.doi.org/10.1124/mol.52.4.613