The pH dependence of NADPH oxidase in human eosinophils

What is it about?

NADPH oxidase is strongly inhibited above or below pHi 7.5, but is not affected by pHo. Surprisingly, electron current in inside-out patches (reflecting the turnover of the enzyme per se) is only weakly sensitive to pHi. Evidently a step in assembly or deactivation of the NADPH oxidase complex accounts for the pH sensitivity in intact cells.

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