What is it about?
Exposure to chronic hypoxia increased ventilation during normoxic and low oxygen conditions. However, the deletion of the transcription factor HIF -1α in glutamatergic neurons of a specific area of the brainstem (nucleus tractus solitarius or NTS) produced a blunted ventilatory response to hypoxia.
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Why is it important?
This work demonstrate for the first time that the potentiated hypoxic ventilatory response in acclimatized mice (a key feature of ventilatory acclimatization to hypoxia) is dependent of HIF-1α expression in the NTS. Also, these differences in ventilation cannot be explained by differences in metabolism and carbon dioxide on ventilatory drive.
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This page is a summary of: Neuronal HIF‐1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia, The Journal of Physiology, February 2020, Wiley, DOI: 10.1113/jp279331.
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