What is it about?
This study describes matched monocytes and macrophages obtained from small volumes of peripheral blood of patients with varying coronary artery disease at the time of coronary angiogram. We found that coronary disease severity correlates directly with circulating CD16+ monocytes and inversely with regulatory M2 macrophages derived ex vivo, and that these associations are independent of age and traditional cardiovascular risk factors.
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Why is it important?
In humans, the data on monocyte subtypes in clinical coronary artery disease has been sparse and sometimes conflicting, and this work strives to pair those subtypes in a novel way with those of derived macrophages across a spectrum of coronary disease.
Perspectives
This article is my laboratory's foray into truly translational research. It stemmed from the initiative by Kathryn Arnold, who has presented this work in excellent fashion at the NIH/NHLBI Unraveling Vascular Inflammation conference at the American College of Cardiology Scientific Sessions. The method to derive macrophages from small volumes of peripheral blood (< 3 cc) is new and has provided our laboratory with a potentially powerful way to study clinical populations.
Francis Alenghat
University of Chicago
Read the Original
This page is a summary of: Monocyte and macrophage subtypes as paired cell biomarkers for coronary artery disease, Experimental Physiology, July 2019, Wiley,
DOI: 10.1113/ep087827.
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