What is it about?

We were asked by the Journal of Physiology to author a "Perspective" on a research article for which we performed a peer review. The study by Chen and Dai systematically probed exercise-induced alterations in spinal interneurons after a chronic treadmill running protocol in mice. Interestingly, a moderately-intense exercise program enhanced the sensitivity and excitability of spinal interneurons.

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Why is it important?

Chen and Dai's study provides a rare example of slice electrophysiology, wherein recordings were taken from spinal interneurons of juvenile mice. By revealing discrete alterations in channel properties that drive exercise-induced plasticity, their work interprets and extends prior observations of this phenomenon, and aids in the development of rehabilitative endeavors.


On a personal note, it was an immense honor to be formally asked by the Journal to author this Perspective with my mentor. It provided a platform by which we could highlight a laudable research article in the context of exercise physiology. Our hope is that the salient work performed by Chen and Dai will be translated to benefit the a patient population.

Bradley Stavros Heit
Northwestern University

Read the Original

This page is a summary of: Treadmill running: more ‘exciting’ than you think, The Journal of Physiology, September 2022, Wiley,
DOI: 10.1113/jp283653.
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