What is it about?

Diabetic nephropathy (DN) is one of the main complications of diabetes. Pyroptosis is a newly discovered inflammatory programmed cell death (PCD), which has been proved to occur in intrinsic cells of kidney and participate in the progression of DN. In this article we aimed to investigate the effect of GSK-3β/HIF-1α pathway on pyroptosis of high-glucose-induced renal tubular cells. Our studies definitively demonstrate that GSK-3β/HIF-1α signaling pathway mediates HG-stimulated pyroptosis in renal tubular epithelial cells and that down-regulation of GSK-3β inhibited HG-induced pyroptosis by inhibiting the expression of HIF-1α. These findings suggest new potential target for the treatment of DN.

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Why is it important?

we demonstrated in vitro that pyroptosis of renal tubular epithelial cells is associated with the increase of GSK-3β activity. Down-regulation of GSK-3β can inhibit pyroptosis of renal tubular epithelial cells induced by HG and may be related to down-regulation of HIF-1α.


We hope this article can find a new promising therapeutic target for preventing DN and its evolution to ESRD.

Jiiayi Wan

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This page is a summary of: Inhibition of the glycogen synthase kinase 3β–hypoxia‐inducible factor 1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells, Experimental Physiology, September 2022, Wiley,
DOI: 10.1113/ep090685.
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