The theoretical tertiary structure of proteins and the topological differences between RhD and RhCE

What is it about?

We identified theoretical structural differences between the four isoforms of RhCE and RhD using computational biological tools.

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Why is it important?

The physicochemical properties of Rh proteins made them different, although their genes are homologous. Using computational biology, we model structures with sufficient precision, similar to those obtained experimentally. An amino acid variation alters the folding of the tertiary structure and the interactions with other proteins, modifying the electrostatic environment, the spatial conformations and therefore the antigenic recognition.