Protection against non-Rhesus alloimmunization by anti-D immunoglobuline.

What is it about?

Anti-D immunoglobuline (Ig) is very effective in preventing RhD alloimmunization, although the precise working mechanism is unknown. We found that anti-D Ig also protects against immunisation by other (non-Rhesus) antibodies. Also ABO-incompatibility has a protective effect.

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Why is it important?

Our findings are helpful in elucidating the possible working mechanism(s) of anti-D Ig. Our results suggest that the working mechanism is not specific for protection against RhD-antibodies.