What is it about?
Today, more than 50 cord blood banks all over the world are processing of umbilical cord blood. Processing of cord blood is performed by two methods, manual or automated. Generally in both methods volume reduction of samples is done using hydroxy- ethyl starch. We have shown that the quality of processed unit was preserved without hydroxy- ethyl starch in one of the most widely used automated methods.
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Why is it important?
Since patients receiving HSC transplants from the UCB supply are children and have severely weakened immune systems, considering the fact that the addition of any substance into the bags of cord blood raises the risk of product contamination, therefore, processing of UCB in the without-HES method can be considered as a step toward reducing this risk.
Perspectives
I hope this article open the new window in choosing better criteria for example total mononuclear cells instead of total nucleated cells and also safer method for processing of cord blood units.
Kamran Atarodi
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine
Read the Original
This page is a summary of: Comparison of human umbilical cord blood processing with or without hydroxyethyl starch, Transfusion, August 2017, Wiley,
DOI: 10.1111/trf.14290.
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