What is it about?
This study determined whether (a) there is concordance between serum MPO and neutrophil and/or monocyte intracellular MPO content; (b) peripheral blood mononuclear cells respond to inflammatory interleukins (ILs) by increasing intracellular signaling.
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Why is it important?
The results presented in this manuscript significantly add to our understanding of the inflammatory response following high-intensity exercise. In particular, evidence has been provided that the first few hours of recovery is a critical time for synthesis and release of MPO by both neutrophils and monocytes, that monocytes with either M1 or M2 phenotypes reduce intracellular IL-6 at the same time that plasma IL-6 is increased, and that STAT3 signaling is activated in monocytes.
Perspectives
How these immune cell responses observed during the early recovery phase may impact on tissue recovery during the subsequent regeneration phase remains a difficult, but necessary path for future investigation.
Dr Mari van de Vyver
Stellenbosch University
Read the Original
This page is a summary of: Neutrophil and monocyte responses to downhill running: Intracellular contents of MPO, IL-6, IL-10, pstat3, and SOCS3, Scandinavian Journal of Medicine and Science in Sports, June 2015, Wiley,
DOI: 10.1111/sms.12497.
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