What is it about?
Individual responses in creatine kinase (CK) release after eccentric exercise are divergent. This study aimed to identify whether this could be related to selected humoral or intramuscular inflammatory factors.
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Why is it important?
Objective cluster analysis uncovered a group of subjects with a characteristic biphasic CK release after DHR. The second elevation was related to their early cytokine response. The results provide evidence that early responses following eccentric exercise are indicative of later variation.
Perspectives
Even though exercise is promoted for health and the reduction of chronic metabolic inflammation, the inflammatory response to exercise is not properly understood. It was thus essential that we better our understanding of these processes. The results of this investigations added to our understanding of individual variability associated with the inflammatory response following eccentric exercise induced tissue damage. It highlighted that early responses are indicative of later variation and that immune cell responses during the early recovery phase may impact on tissue recovery.
Dr Mari van de Vyver
Stellenbosch University
Read the Original
This page is a summary of: Variable inflammation and intramuscular STAT3 phosphorylation and myeloperoxidase levels after downhill running, Scandinavian Journal of Medicine and Science in Sports, January 2014, Wiley,
DOI: 10.1111/sms.12164.
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