What is it about?
The aim of this meta-analysis was to evaluate the efficacy and safety of duloxetine for management of osteoarthritis knee (OAK) pain.
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Why is it important?
This analysis suggests duloxetine (60/ 120 mg quaque die (QD)), compared with placebo control, resulted in a greater reduction in pain, improved function and patient-rated impression of improvement, and acceptable adverse effects for the treatment of OAK pain after approximately 10-13 weeks of treatment.
Perspectives
Duloxetine is effective and safe for osteoarthritis knee (OAK) pain, but it should be realized that the beneficial effect of duloxetine on OAK pain still needs to be confirmed in rigorously designed multicenter, doubleblind, randomized, and large-scale controlled trials are required.
Dr Shengying Shi
Southern Medical University
Read the Original
This page is a summary of: Efficacy and Safety of Duloxetine on Osteoarthritis Knee Pain: A Meta-Analysis of Randomized Controlled Trials, Pain Medicine, June 2015, Oxford University Press (OUP),
DOI: 10.1111/pme.12800.
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