What is it about?
Human cancer is caused by genetic and environmental component. This historical review covers genetic (SNP, GWAS, candidate gene such as CYP) and environmental (Smoking, diet, and adductomics as a brand new discipline) components. Histological perspectives especially lung cancer also added our possible understanding the cause of cancer.
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Why is it important?
The review provide the important basis of understandding such as mutation signature, an advanced form of gene-environmental perspectives (particular cause such as Aristolochic acid cause a particular cancer, in this case , urothelial cancer having T>A mutation.
Perspectives
Combined approach of adductomics and high throughput mutation signature analysis would give us a new clue to comprehensive understanding of human carcinogenesis.
Prof. Haruhiko Sugimura
Hamamatsu University School of Medicine
Read the Original
This page is a summary of: Susceptibility to human cancer: From the perspective of a pathologist, Pathology International, May 2016, Wiley,
DOI: 10.1111/pin.12418.
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