What is it about?
Human cancer is caused by genetic and environmental component. This historical review covers genetic (SNP, GWAS, candidate gene such as CYP) and environmental (Smoking, diet, and adductomics as a brand new discipline) components. Histological perspectives especially lung cancer also added our possible understanding the cause of cancer.
Why is it important?
The review provide the important basis of understandding such as mutation signature, an advanced form of gene-environmental perspectives (particular cause such as Aristolochic acid cause a particular cancer, in this case , urothelial cancer having T>A mutation.
The following have contributed to this page: Prof. Haruhiko Sugimura
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