What is it about?
Challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences.
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Why is it important?
Immunotherapies and genomics have led to unprecedented improvement in the overall survival of cancer patients. Due to the high mutational load, melanoma continues to be on the forefront to innovate with new strategies to combat the disease. The work introduces how all clinical and basic dermatological disciplines can benefit from such findings.
Perspectives
Accelerated by next generation sequencing, we are just starting to discover the wealth and breadth of the field in melanocyte and melanoma research. The skin-colored pigment in our skin is produced by melanocytes, designed to absorb dangerous UV radiation. A life-threatening form of skin cancer, melanoma, arises, when pigment-producing melanocytes undergo cancerous transformation. Lack of pigment production in albinism patients, patched loss of pigmentation called vitiligo, or on the other end of the spectrum, post-inflammatory- hyperpigmentation called melisma, and prevention of the diseases are on the frontlines of dermatology and pigment cell research identified in the work entitled Frontiers in pigment cell and melanoma research published today in the Wiley Journal Pigment Cell and Melanoma Research. https://doi.org/10.1111/pcmr.12728
Fabian Filipp
University of California Merced
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This page is a summary of: Frontiers in pigment cell and melanoma research, Pigment Cell & Melanoma Research, October 2018, Wiley,
DOI: 10.1111/pcmr.12728.
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