What is it about?
This review highlights the current knowledge about the effectiveness and safety of dietary supplements in the multimodal management of chronic pain. Through the analysis of literature and their it has been proposed a new mechanism of action a pain mechanism-based approach to their use.
Photo by julien Tromeur on Unsplash
Why is it important?
Dietary supplements are even more utilized in chronic pain even though it is not often clear their real effectiveness and safety. At the same time there is a huge unmet need of new drugs for treating chronic pain as those presently available, even though effective, raise some concerns about their safety (opioids) or their side effects (anticonvulsants, antidepressants and NSAIDs). Hence, a more personalized approach, based on an expanded list of pain modulators exploiting novel mechanisms is required in order to design patient tailored interventions. In this perspective, there is the need to better summarize not only the effectiveness of dietary supplements but also to describe how they exactly exert their pain modulating activity. interestingly, dietary supplements can act on pain mechanism through modes of action that are not covered by “traditional” drugs. For this reason we propose the new approach in considering dietary supplements part of multimodal approach to treat chronic pain with a special focus on chronic postoperative pain and low back pain
Read the Original
This page is a summary of: Non‐drug pain relievers active on non‐opioid pain mechanisms, Pain Practice, September 2021, Wiley, DOI: 10.1111/papr.13073.
You can read the full text:
The following have contributed to this page