What is it about?
Alcohol consumption is a risk factor for oral cancer, possibly via its conversion to acetaldehyde, a known carcinogen. The oral commensal yeast Candida albicans may be one of the microorganisms responsible for this conversion intra-orally. In this study, it is shown that C. albicans Adh1p is the enzyme responsible for the conversion of ethanol to acetaldehyde.
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Why is it important?
Our findings show that, C. albicans may play a role in the cancerous progression of potentially malignant oral lesions with chronic candidal infection, through the conversion of ethanol to acetaldehyde.
Perspectives
A link between C. albicans and oral cancer has been suggested since the 1960s. The alcohol dehydrogenase (Adh) family of enzymes are involved in acetaldehyde metabolism in yeast but, for C. albicans it is not known which family member is responsible for the conversion of ethanol to acetaldehyde. We conclude form this study that CaAdh1p is the enzyme responsible for ethanol use under in vitro growth conditions, and may contribute to the intra-oral production of acetaldehyde.
Marina M Bakri
University of Malaya
Read the Original
This page is a summary of: In vitroexpression ofCandida albicansalcohol dehydrogenase genes involved in acetaldehyde metabolism, Molecular Oral Microbiology, September 2014, Wiley,
DOI: 10.1111/omi.12064.
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