What is it about?
Fibroblasts are important cells for wound healing and their biological function is modulated by several factors including growth factors, cytokines and matrix molecules. These may change their phenotype inducing, for example, their differentiation into myofibroblasts. In this review, the role of myofibroblasts in wound healing is analyzed in the context of periodontal wounds.
Featured Image
Why is it important?
Myofibroblasts are critically important for matrix reconstitution. Periodontal tissues are composed of large amounts of type I collagen, present in the soft connective tissues and bone. Therefore, myofibroblastic differentiation is critically important for proper tissue regeneration.
Perspectives
Understanding and, hopefully, controlling, the response of tissue regeneration is critically important for the development of scientifically sound therapies in periodontology. Unfortunately, we still do not know too much about the phenotypes and responses of periodontal tissues during normal and pathological wound healing.
Dr Patricio C Smith
Read the Original
This page is a summary of: Role of myofibroblasts in normal and pathological periodontal wound healing, Oral Diseases, February 2018, Wiley,
DOI: 10.1111/odi.12773.
You can read the full text:
Contributors
The following have contributed to this page
