What is it about?
In this study, we investigated if small and common differences in a gene that forms a protein important for the formation of the kidneys and urinary tract have a relation with a frequent malformation of the kidneys and urinary tract. We found that small variances of these gene are more frequent in children with a obstruction between the kidney and the channel that drains the urine called ureteropelvic junction obstruction.
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Why is it important?
We found that children with an specific malformation of the kidney have small variations in a gene that produces a receptor important for the normal formation of the kidney and urinary tract in Brazilian population.
Perspectives
The knowledge of the genes responsible for malformations of the kidneys and urinary tract may help understanding the normal formation and may open future possibilities for gene therapy.
Prof Ana Cristina Simões e Silva
Universidade Federal de Minas Gerais
Read the Original
This page is a summary of: Association of angiotensin type 2 receptor gene polymorphisms with ureteropelvic junction obstruction in Brazilian patients, Nephrology, October 2014, Wiley,
DOI: 10.1111/nep.12308.
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