Alzheimer's disease tau pathology in the brainstem

What is it about?

Qualitative evidence has shown that Alzheimer's disease tau pathology appears in brainstem nuclei before it appears in the cortex. In this study, the burden of this pathology is quantified at different stages in the locus coeruleus and dorsal raphe nucleus to better understand this phenomenon.

Featured Image

Why is it important?

Successful treatment of Alzheimer's disease will likely require diagnosing and targeting the disease at early stages when the pathology is limited. By understanding how the pathology progresses in these nuclei, we can potentially diagnose patients earlier and develop more targeted treatments.