Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid‐shaped cells of Streptococcus pneumoniaeD39

What is it about?

This paper establishes RodZ as an essential scaffolding protein required for the hierarchical assembly and function of the elongasome that synthesizes peripheral peptidoglycan (pPG) in Streptococcus pneumoniae, which lacks an MreB homolog. This paper also reports synthetic-viable, suppressor relationships between Class A penicillin-binding proteins (PBPs) and components of the core pPG elongasome. A bypass model for modulation of pPG elongasome function is proposed to account for these genetic relationships that restore viability.

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