Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine

What is it about?

Listeria monocytogenes is an environmental bacterial pathogen that depends upon secreted proteins for survival within the infected host; proper folding of these proteins requires the secretion chaperone PrsA2. Described here is the characterization of a two-component signal transduction system PieRS that regulates prsA2 expression as well as an additional chaperone and genes of unknown function. The PieRS regulon confers bacterial resistance to ethanol exposure and contributes to bacterial survival during transit through the gastrointestinal tract.

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