EhRho6‐mediated actin degradation in Entamoeba histolytica is associated with compromised pathogenicity

What is it about?

Entamoeba histolytica is the causative agent for amoebiasis and has an adverse impact on the healthcare systems in the developing countries, therefore, affect the socio-economic status of the human population. The transmission of this pathogen from one host to another depends on its ability to undergo encystation. In this study, we identified a novel EhRhoGEFduo and its substrate RhoGTPases. Furthermore, our results indicate the existence of Rho family members in amoeba which are involved in the actin degradation and we hypothesize its implications in amoebic encystation. This study is the first report of Rho family members associated with the degradation of actin in E. histolytica.

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