Perturbation of ATG16L1 function impairs the biogenesis of Salmonella and Coxiella replication vacuoles

What is it about?

Bacterial pathogens that invade human cells must manipulate the human cell to engineer an environment that supports pathogen replication. S. Typhimurium, a common cause of gastroenteritis, uses the effector protein SopF to maintain the membrane-bound Salmonella-containing vacuole and block host xenophagy. This study demonstrates that these two traits are functionally linked. Furthermore, we demonstrate the utility of SopF as a tool to dissect the impact of xenophagy vs autophagy during infection with the intracellular bacterial pathogen Coxiella burnetii.

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