Mrr1 regulation of methylglyoxal catabolism and methylglyoxal‐induced fluconazole resistance in Candida lusitaniae

What is it about?

The transcription factor Mrr1 is closely associated with multidrug resistance in Candida species, but little is understood about its natural role in Candida biology. Here, we report that in Candida lusitaniae, Mrr1 regulates expression of enzymes involved in catabolism of the toxic metabolite methylglyoxal. In addition, methylglyoxal induces fluconazole resistance in a partially Mrr1-dependent manner in C. lusitaniae.

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