RnhP is a plasmid‐borne RNase HI that contributes to genome maintenance in the ancestral strain Bacillus subtilis NCIB 3610

What is it about?

Cells constantly accumulate RNA-DNA hybrids throughout the chromosome that compromise genome integrity if the RNA component is not removed. We identify a previously uncharacterized plasmid encoded gene that cleaves RNA-DNA hybrids to promote genome integrity but not plasmid maintenance or hyper-replication

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