Regulatory circuits controlling Spx levels in Streptococcus mutans

What is it about?

Streptococcus mutans encodes two Spx homologues. SpxA1 is resistant to ClpP proteolysis due to the presence of C-terminal acidic residues, transcriptionally regulated by the metalloregulators PerR and SloR, and relies on its redox sensing motif to activate an oxidative stress response. SpxA2 levels are controlled by the LiaFSR signal transduction system and posttranslationally by ClpP proteolysis. In addition, SpxA2 was critical for the growth of S. mutans under envelope stress conditions regardless of its redox status.

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