Analysis of the CodY RNome reveals RsaD as a stress‐responsive riboregulator of overflow metabolism in  Staphylococcus aureus

What is it about?

Understanding the mechanisms by which Staphylococcus aureus adapts to the constraints of the diverse host niches in which it inhabits is critical to developing novel treatments. The current study examines the role of global regulator CodY in regulating small RNAs (sRNAs), and shows that one, RsaD, is a trans-acting sRNA that affects carbon overflow metabolism. In doing so, RsaD fine-tunes acetate and acetoin production to regulate cell death during stationary phase.

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