BldD, a Master Developmental Repressor, Activates Antibiotic Production in Two Streptomyces Species

What is it about?

BldD sits at the top of regulatory cascade controlling morphological development of Streptomyces. It generally functions as a repressor of genes involved in aerial hyphae formation and sporulation. We revealed for the first time that BldD activates antibiotic biosynthesis in Streptomyces both directly and via a cascade mechanism. Our findings provide novel insights into the cellular roles of BldD, and help to clarify the complex regulatory mechanisms of antibiotic production and rationally construct antibiotic overproducers.

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