What is it about?
Drug resistance to antibiotics is a growing problem. We make an argument that a bacterial channel that serves as an "emergency release valve" for the cell to survive some environmental insults is a viable drug target. Activators of this channel may not only decrease bacterial growth, but also allow passage of additional antibiotics into the bacterial cell.
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Why is it important?
Drug resistance to antibiotics is a growing problem.
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This page is a summary of: An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics, Molecular Microbiology, June 2019, Wiley,
DOI: 10.1111/mmi.14325.
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