Bacillus subtilis FolE is sustained by the ZagA zinc metallochaperone and the alarmone ZTP under conditions of zinc deficiency

Pete Chandrangsu, Xiaojuan Huang, Ahmed Gaballa, John D. Helmann
  • Molecular Microbiology, May 2019, Wiley
  • DOI: 10.1111/mmi.14314

What is it about?

Under zinc limiting growth conditions, many bacteria express a COG0523 family protein postulated to function as a metallochaperone. Here, we provide evidence that the B. subtilis ZagA (formerly YciC) metallochaperone helps to sustain function of the FolE enzyme when zinc levels fall, and this function depends on the alarmone ZTP that accumulates in folate-deficient cells.

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The following have contributed to this page: John Helmann

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