Aurora kinase Ipl1 facilitates bilobed distribution of clustered kinetochores to ensure error‐free chromosome segregation in Candida albicans

What is it about?

Candida albicans is a budding yeast. Although primarily a commensal of humans, it may turn into a pathogen and can even tolerate high concentrations of antifungal drugs. We show that the evolutionarily conserved Aurora B kinase Ipl1 regulates ploidy of cells by maintaining microtubule dynamics and the bilobed organization of kinetochore clusters. Depletion of Ipl1 results in erroneous kinetochore-microtubule attachments resulting in aneuploidy which helps the organism to survive better in the presence of anti-fungal drugs.

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