Systematic analysis of the Myxococcus xanthus developmental gene regulatory network supports posttranslational regulation of FruA by C‐signaling

What is it about?

The bacterium Myxococcus xanthus undergoes multicellular development when starved. Commitment to spore formation involves C-signal-dependent activation of the transcription factor FruA, but the mechanism is poorly understood. Our systematic experimental and computational analyses support a model in which C-signaling activates FruA at least ninefold posttranslationally by a mechanism other than phosphorylation.

Featured Image