Role of the global regulator Rex in control of NAD + ‐regeneration in Clostridioides (Clostridium) difficile

What is it about?

Clostridioides difficile is a major pathogenic bacterium that is responsible for large numbers of human infections that cause diarrhea and pseudomembranous colitis. Two proteins, PrdR and Rex, were found to control the expression of a large number of genes involved in metabolism, including those whose activities lead to production of butyrate, a factor that stimulates the expression of the major C. difficile toxin genes.

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