Deciphering the essentiality and function of the anti‐σ M factors in Bacillus subtilis

Heng Zhao, Daniel M. Roistacher, John D. Helmann
  • Molecular Microbiology, February 2019, Wiley
  • DOI: 10.1111/mmi.14216

What is it about?

Regulation of gene expression in response to stress often involves alternative sigma factors, many of which are positively autoregulated. Here, we show that the absence of the corresponding negative regulators (anti-sigma factors) can lead to a runaway amplification of the response with lethal consequences, and we define mechanisms that can allow cells to survive this dysregulation.

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