Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection

What is it about?

Diarrheal infections are a major cause of illness and death worldwide; better understanding of how diarrhea-causing bacteria infect their host could allow improved strategies for preventing and treating infections. Here, we use a mouse model of bacterial diarrhea to understand how bacteria maintain integrity of their cell lining (the cell envelope) during infection. We find that bacteria require two proteins that repair damage to other envelope proteins in order to cause infection.

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