What is it about?
The gene pa0124 encodes a ParE-type toxin that can inhibit DNA gyrase. While high concentrations mediate toxicity by inhibiting gyrase, leading to dsDNA breaks, low concentrations offer some protection against antibiotics, particularly those that target DNA gyrase. This is a unique spectrum of phenotypic outcomes for the ParE toxin family highlighting concentration-dependent protective to deleterious functions.
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Why is it important?
This hints that one way cell's can mediate phenotypic tolerance to anti-gyrase treatments uses ParE toxins.
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This page is a summary of: The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa
offers protection to cells challenged with anti-gyrase antibiotics, Molecular Microbiology, November 2018, Wiley,
DOI: 10.1111/mmi.14165.
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