Negative regulation of Candida glabrata Pdr1 by the deubiquitinase subunit Bre5 occurs in a ubiquitin independent manner

What is it about?

Candida glabrata is an emerging fungal pathogen. This yeast can acquire azole resistance at high frequency. The most common forms of azole resistant C. glabrata are caused by changes in the gene encoding an important transcription factor Pdr1. Pdr1 controls expression of genes that directly act to detoxify azole drugs. Here we identify a novel regulator of the activity of Pdr1 called Bre5. Although Pdr1 and Bre5 are conserved with the laboratory yeast Saccharomyces cerevisiae, the regulatory relationship seen in C. glabrata is not.

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