Genetic dissection of the secretory route followed by a fungal extracellular glycosyl hydrolase

What is it about?

We used an Aspergillus nidulans inulinase denoted InuA and a panel of mutations affecting different steps of intracellular traffic to investigate the route by which a secreted enzyme is delivered to the extracellular medium. Although the enzyme follows a conventional secretory pathway involving the Golgi apparatus, its delivery outside cells requires functional early endosomes.

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