Expression and regulation of the Pseudomonas aeruginosa hibernation promoting factor

What is it about?

Biofilms contain bacteria in a variety of different physiological states, including subpopulations of dormant cells. While dormant, bacteria must maintain the integrity of ribosomes, which are required for resuscitation from dormancy. The hibernation promoting factor (HPF) is a small protein that is necessary for ribosome preservation during dormancy. We characterized the mechanisms that control production of HPF in P. aeruginosa, and demonstrate that regulation of HPF is complex, requiring both transcriptional and post-transcriptional processes.

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