The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii

What is it about?

Despite its clinical importance, relatively little is known about the molecular basis of <i>Acinetobacter baumannii</i> pathogenesis. Using a transposon-sequencing (Tn-Seq) screen and the mouse model of bloodstream infection, we identified the lytic transglycosylase MltB as being a critical fitness factor in <i>A. baumannii</i>. In this study, we showed that MltB is part of a complex network connecting resistance to stresses, cell envelope homeostasis, biogenesis of pili and <i>in vivo fitness</i>.

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