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In this study we show that the diarrheal pathogen Vibrio cholerae contains a chemoreceptor called Aer2 that senses oxygen. Oxygen is sensed via two related but functionally divergent PAS-heme domains (PAS1 and PAS2) within Aer2. The PAS2 domain is an oxygen sensor, whereas the PAS1 domain modulates PAS2 signaling by binding oxygen. The structure of a signal-on PAS2 variant was solved. This structure supports a previously proposed signaling model.

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This page is a summary of: THE AER2 RECEPTOR FROM VIBRIO CHOLERAE IS A DUAL PAS-HEME OXYGEN SENSOR, Molecular Microbiology, May 2018, Wiley,
DOI: 10.1111/mmi.13978.
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