Regulons and Protein-Protein Interactions of PRD-containing Bacillus anthracis Virulence Regulators Reveal Overlapping but Distinct Functions

What is it about?

Multiple transcription regulators control Bacillus anthracis virulence. We show that three regulators, AtxA, AcpA, and AcpB, predicted to have similar protein structures, have overlapping but distinct functions. Together they control hundreds of genes, which are affected by one, two, or all three regulators. Targeted genes include classic virulence genes and multiple other genes associated with bacterial physiology. Relative levels of the regulators and interactions between the regulators can affect target gene expression.

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