The low-molecular-mass, penicillin-binding proteins DacB and DacC combine to modify peptidoglycan cross-linking and allow stable Type IV pilus expression in Neisseria gonorrhoeae

What is it about?

The composition and architecture of the bacterial cell wall is an essential factor in proper growth and communication of the bacterium with the outside world. This work shows that inactivation of two proteins that modify the cell wall of Neisseria gonorrhoeae, the bacterium that causes gonorrhea, produces viable bacterial cells that actually grow faster but are more sensitive to antibiotics and no longer express a major virulence factor.

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