Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis

Daniel F. Rojas-Tapias, John D. Helmann
  • Molecular Microbiology, December 2017, Wiley
  • DOI: 10.1111/mmi.13906

What is it about?

In Bacillus subtilis, the Spx transcription factor regulates the expression of genes induced by disulfide stress. Here, the Spx transcription factor is also shown to be induced by cell wall stress through activation of the SigM alternative sigma factor, and this induction contributes to cell survival. In contrast with disulfide stress, Spx remains largely in its reduced state after cell wall stress.

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