Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa

Rebecca J. Edgar, Georgina E. Hampton, G. Patricia Casas Garcia, Megan J. Maher, Matthew A. Perugini, David F. Ackerley, Iain L. Lamont
  • Molecular Microbiology, October 2017, Wiley
  • DOI: 10.1111/mmi.13855

What is it about?

In Pseudomonas aeruginosa production and uptake of a siderophore pyoverdine is regulated through the combined actions of two sigma factors, σ FpvI and σ PvdS, and an antisigma protein FpvR20. We show that FpvR20 has similar affinity for both sigma factors. The amount of FpvR20 is less than the total amount of sigma factor protein, allowing basal expression of target genes, and FpvR20 is degraded in the presence of pyoverdine increasing activity of the sigma factors.

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