Non-canonical activation of histidine kinase KdpD by phosphotransferase protein PtsN through interaction with the transmitter domain

What is it about?

Bacteria use two-component systems to sense environmental stimuli and to transduce these signals into a cellular response. In some cases, activity of these systems can also be modulated from inside the cell through protein-protein interaction. Here we describe how interaction with an accessory protein triggers activation of a two-component system independent of its cognate signal.

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