Wing phosphorylation is a major functional determinant of the Lrs14-type biofilm and motility regulator AbfR1 in Sulfolobus acidocaldarius

Lingling Li, Ankan Banerjee, Lisa Franziska Bischof, Hassan Ramadan Maklad, Lena Hoffmann, Anna-Lena Henche, Fabian Veliz, Wolfgang Bildl, Uwe Schulte, Alvaro Orell, Lars-Oliver Essen, Eveline Peeters, Sonja-Verena Albers
  • Molecular Microbiology, July 2017, Wiley
  • DOI: 10.1111/mmi.13735

What is it about?

The DNA-binding protein AbfR1, which belongs to the archaea-specific Lrs14 family, regulates biofilm formation in the crenarchaeon Sulfolobus acidocaldarius. In this work, we demonstrate that AbfR1 employs a novel wHTH DNA-binding mode and that previously identified phosphorylation sites located on the wing are important for DNA binding. Their phosphorylation appears to influence the function of AbfR1 and thus, the regulation of biofilm formation and motility in S. acidocaldarius.

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The following have contributed to this page: Professor Sonja-Verena Albers, Dr Ankan Banerjee, and Professor Lars-Oliver Essen