Global regulatory roles of the cAMP/PKA pathway revealed by phenotypic, transcriptomic and phosphoproteomic analyses in a null mutant of the PKA catalytic subunit in Candida albicans

What is it about?

The human fungal pathogen Candida albicans causes both superficial and life-threatening infections in immunocompromised people. We report that the PKA catalytic subunit, a central regulator of virulence in C. albicans, is not essential for cell growth but required for phenotypic transitions.

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