The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments

What is it about?

MmpL transporters are membrane proteins, particularly abundant in non-tuberculous mycobacteria. Herein, we review their role in the transport of a diverse family of substrates that include lipid and non-lipid molecules, in cell envelope assembly and/or in growth and pathogenicity. We also discuss their implication in drug resistance mechanisms and in the vulnerability of pathogenic mycobacteria.

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