What is it about?
Cells of the budding yeast K. lactis lacking the phosphorelay system are viable and resistant to hyperosmotic stress. In K. lactis there is a strong negative feedback that turns off the osmotic signalling.
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Why is it important?
In contrast to S. cerevisiae, in K. lactis there is a strong negative feed back that downregulates the high osmolarity glycerol pathway and avoids constitutive activation of Hog1.
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This page is a summary of: Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeastKluyveromyces lactis, Molecular Microbiology, March 2017, Wiley,
DOI: 10.1111/mmi.13664.
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